Provided herem are methods and compositions for generating engineered cells,such as cells expressing a recombinantreceptor, including methods involving stimulation and/or engmeering of aninput composition having a defined ratio of naive-like CD4+T cells to naive- like CD8+ T cells In particular, the methods can be used toengineer T cells with genetically engineered receptors,such as genetically engineered antigen receptors such as engineered(recombinant) TCRs and chimeric antigen receptors (CARs), orother recombinant chimeric receptors Features of the methods include producinga more consistent and/or predictable T cell productand/or a product with lower toxicity compared with other methods
