The invention provides a composition including at least one iron chelating compound and at least one antifungal agent. The composition can include the iron chelating compounds deferiprone or deferasirox. An antifungal agent included in the composition can include a polyene antifungal agent, an azole antifungal agent or an echinocandin antifungal agent. The invention also provides a method of treating or preventing a fungal condition. The method includes administering to an individual having, or susceptible to having, a fungal condition a therapeutically effective amount of at least one iron chelating compound for a sufficient time to reduce the severity of a fungal condition, wherein the iron chelating compound comprises a non-siderophore or non-xenosiderophore relative to the fungal condition. A method of treating or preventing a fungal condition provided by the invention also can include administering to an individual having, or susceptible ofhaving,a fungal condition a therapeutically effective amount of at least one iron chelating compound and at least one antifungal agent. Provided further by the invention is a method including prophylactic administration of the at least one iron chelating compound or at least one iron chelating compound and at least one antifungal agent prior to onset of the fungal condition.本發明提供包括至少一種鐵螯合化合物及至少一種抗真菌劑之組合物。該組合物可包括鐵螯合化合物去鐵酮(deferiprone)或去鐵斯若(deferasirox)。組合物中所包括之抗真菌劑可包括多烯抗真菌劑、唑類抗真菌劑或棘白菌素(echinocandin)抗真菌劑。本發明亦提供治療或預防真菌病狀之方法。該方法包括向患有或易患真菌病狀之個體投予治療有效量之至少一種鐵螯合化合物歷經足以降低真菌病狀嚴重程度之時間,其中該鐵螯合化合物包含與該真菌病狀相關之非鐵載體(non-siderophore)或非異源鐵載體(non-xenosiderophore)。本發明提供之治療或預防真菌病狀之方法亦可包括向患有或易患真菌病狀之個體投予治療有效量之至少一種鐵螯合化合物及至少一種抗真菌劑。本發明進一步提供的方法包括在真菌病狀發作之前預防性投予至少一種鐵螯合化合物或至少一種鐵螯合化合物及至少一種抗真菌劑。(無元件符號說明)
