Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
发明人:
Spellberg, Brad J.,Ibrahim, Ashraf S.,Edwards, John E.
申请号：
AU2007272781
公开号：
AU2007272781B2
申请日:
2007.07.13
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention provides a composition including at least one iron chelating compoundand at least one antifungal agent. The composition can include the iron chelatingcompounds deferiprone or deferasirox. An antifungal agent included in the compositioncan include a polyene antifungal agent, an azole antifungal agent or an echinocandinantifungal agent. The invention also provides a method of treating or preventinga fungal condition. The method includes administering to an individual having,or susceptible to having, a fungal condition a therapeutically effective amountof at least one iron chelating compound for a sufficient time to reduce the severityof a fungal condition, wherein the iron chelating compound comprises a non-siderophoreor non-xenosiderophore relative to the fungal condition. A method of treatingor preventing a fungal condition provided by the invention also can include administeringto an individual having, or susceptible of having, a fungal condition a therapeuticallyeffective amount of at least one iron chelating compound and at least one antifungalagent. Provided further by the invention is a method including prophylacticadministration of the at least one iron chelating compound or at least one ironchelating compound and at least one antifungal agent prior to onset of the fungalcondition.
