The invention relates to medicine, pharmaceuticals and biotechnology and relates to methods for the maximum delivery of medicinal or biologically active substances to the gastrointestinal tract using drug delivery systems (SDLs) based on food biopolymers for the purpose of their controlled release. The present invention relates to the creation of new improved compositions for the delivery of readily degradable, poorly soluble biologically active and medicinal substances (drugs) in the stomach and to reduce their side effects on the human body, as well as to improved compositions for the treatment of infectious, inflammatory and cancer chemotherapy . The development of systems based on biocompatible biopolymers from food products and their implementation in practice, as a new generation of functional food, provides patients with a number of facilitations in dosage, administration, improves bioavailability and reduces side effects of the active ingredient. The proposed invention developed new SDL based on carboxyl-containing polysaccharides (cellulose ethers and pectins of various origin) and corn zein. It was found that the degree of saturation with the drug differs depending on the structural features of pectin polysaccharides and the method of formation of microspheres. It is shown that, using pectins of various origins, it is possible to obtain complexes with certain characteristics, with a given composition, structure and degree of saturation of the drug. Based on kinetic studies, the process of formation of zein-pectin hydrogels with various pectins was established, the mechanism of the release of model drug from them by changing the type and ratio of biopolymers was revealed, which allows controlling the diffusion rate and is necessary when creating matrix prolonged systems for controlled drug release. Thus, this invention opens the way to the creation of a new generation of dosage forms with improved pharmacokinetic properties, especially for drugs with pronou
