LEVASSEUR PREMAVATHY,PACE JOHN L.,COLEMAN KENNETH,LOWTHER JOHN
申请号：
CO11043791
公开号：
CO6361930A2
申请日:
2011.04.08
申请国别(地区):
CO
年份:
2012
代理人:
摘要：
The Invention relates to the combination of nitrogen Heterocyclic antibacterial compounds of formula (i) with other antibacterial compounds and their use as medicines.Nitrogenous Heterocyclic compounds corresponding to the General formula (i) wherein R1 represents a radical NH2 (CH2) n - or N - (CH2) NHR, R is an alkyl (C1 - C6) and N being equal to 1 or 2； R2 represents a hydrogen Atom； R3 and R4 form a An aromatic nitrogen heterocycle Tico with 5 vertices containing 1,2 or 3 u00e1tomos nitrogen clusters eventually replaced by one ovaries R ', where r' is selected from the group consisting of a hydrogen Atom and alkyl Radicals containing from 1 to 6 carbon ATOMS, in the free form, zwitterions, and forms salts with acids and bases Mineral or organic pharmaceutically acceptable.Other antibacterial agents are chosen from the Group comprising beta lactam penicillins, monobactamos, possibly combined with an inhibitor of beta lactamases, the glycylcyclines, aminoglycosides, tetracyclines, quinolones, glycopeptides, lipop u00e9p We, the quet u00f3lidos, macrolides, Lincosamides, Streptogramins, the oxazolidinones,The polymyxin antibiotics and other known compounds with Therapeutic activity on Pseudomonas aeruginosa and Enterobacteriaceae.La invención se refiere a la combinación de compuestos heterocíclicos nitrogenados antibacterianos de fórmula (I) con otros compuestos antibacterianos y su utilización como medicamentos.Los compuestos heterocíclicos nitrogenados responden a la fórmula general (I)en la que R1 representa un radical (CH2)n-NH2 o (CH2)n-NHR, siendo R un alquilo (C1-C6) y siendo n igual a 1 ó 2；R2 representa un átomo de hidrógeno；R3 y R4 forman juntos un heterociclo nitrogenado de carácter aromático con 5 vértices que contienen 1, 2 ó 3átomos de nitrógeno eventualmente sustituido por uno ovarios agrupamientos R', siendo R' elegido del grupo constituido por un átomo de hidrógeno y los radicales alquilo contienen de 1 a 6 átomos de carbono, en forma libre, de zw
