CELLULES DEFICIENTES EN HLA DE CLASSE II, CELLULES DEFICIENTES EN HLA DE CLASSE I APTES A EXPRIMER DES PROTEINES DE HLA DE CLASSE II, ET LEURS UTILISATIONS
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人:
RUSSELL, DAVID W.,HIRATA, ROLI K.
申请号：
CA3085032
公开号：
CA3085032A1
申请日:
2013.03.15
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a human leukocyte antigen (HLA) class II-related gene, which results in deficiency in MHC class II expression and function. This invention also provides isolated cells further comprising a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in HLA class I/class II deficiency. Also provided are the method of using the cells for transplantation and treating a disease condition.
