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Tricyclic nu-heteroaryl-carboxamide derivatives containing a benzimidazole unit, method for preparing same and their therapeutic use
专利权人:
Sanofi-Aventis
发明人:
Machnik, David,Gille, Catherine,Evanno, Yannick,Rakotoarisoa, Nathalie,Malanda, Andre,Dubois Laurent,Even, Luc
申请号:
AU2007211399
公开号:
AU2007211399B2
申请日:
2007.02.01
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention concerns tricyclic -heteroaryl-carboxamidederivatives containing a benzimidazole unit, of general formula (I) wherein:A represents, with the C-N bond of the benzimidazole unit to which it is bound,a 4- to 7-membered monocyclic heterocycle or a monocyclic heteroaryl containingfrom one to three heteroatoms selected among O, S or N, including the nitrogenatom of the benzimidazole unit; P represents a 8-, 9-, 10-, 11-membered bicyclicheterocycle or a bicyclic heteroaryl, comprising 1 to 6 heteroatoms selectedamong N, O or S; R represents on to four atoms or groups, identical ordifferent; Y represents an oxygen or sulfur atom; R represents a hydrogenatom, a halogen atom, a CC-alkyl, C-C-cycloalkyl, C-C-cycloalkyl-C-C-alkylene,CC-fluoroalkyl or CC-alkoxygroup; R represents from one to three atoms or groups, identical ordifferent; in base or acid addition salt state as well as in hydrate or solvateform. The invention also concerns a method for preparing the compounds and theirtherapeutic use.
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