PROBLEM TO BE SOLVED: To provide an opioid abuse prevention formulation comprising opioid, specifically oxycodone hydrochloride trihydrate, with high content uniformity, the formulation allowing the surface of a tablet, even when a coating agent is coated thereon, to have no asperity and no crack in a coating.SOLUTION: According to the present invention, there is provided an opioid abuse prevention formulation, which can be produced by mixing mixed powder in which oxycodone hydrochloride trihydrate and an additive are mixed at a high shear force, or by mixing the mixed powder as granules to produce the formulation having high content uniformity. Furthermore, the formulation is coated with a coating material, cured, and then coated to provide the surface of a tablet with no asperity and no crack in a coating.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】オピオイド、特にオキシコドン塩酸塩三水和物を含有し、含量均一性が高く、コーティング剤を被覆しても、錠剤表面に凹凸がなく、被膜に割れが生じないオピオイド乱用防止製剤を提供する。【解決手段】オキシコドン塩酸塩三水和物および添加剤を含有する混合粉末を高剪断剪断力で混合し、または顆粒として混合することにより、含量均一性が高い製剤を製造することができ、さらに被覆材を被覆、キュアリング、その後被覆することによって、錠剤表面に凹凸がなく、被膜に割れが生じないオピオイド乱用防止製剤を製造することができる【選択図】なし
