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COMPOSITIONS À BASE DE GLYCOPEPTIDES
专利权人:
Taiwan Hopax Chems. Mfg. Co., Ltd.;Board of Regents, The University of Texas System
发明人:
申请号:
EP06004026.8
公开号:
EP1698351B1
申请日:
2006.02.28
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The invention includes glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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