PROBLEM TO BE SOLVED: To provide an inositol-trisphosphate receptor expression inducer for an inositol-trisphosphate receptor associated with the keratinization of the skin or scalp or the hair restoration of the cells of the hair and to provide various compositions having expression inductive action of inositol-trisphosphate receptors (cosmetic compositions, pharmaceutical compositions, and food and drink compositions).SOLUTION: The present invention provides an inositol-trisphosphate receptor expression inducer containing the extract of the peels or fruits of Citrus reticulata, and various compositions (cosmetic compositions, pharmaceutical compositions, and food and drink compositions) having expression inductive action of inositol-trisphosphate receptors of Citrus reticulata extract.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】皮膚や頭皮の角化又毛髪の細胞の育毛に関連するイノシトール三リン酸受容体に対する、イノシトール三リン酸受容体発現誘導剤、更に、イノシトール三リン酸受容体の発現誘導作用を有する各種組成物(化粧料組成物、医薬組成物、飲食品組成物)の提供。【解決手段】マンダリンオレンジの果皮又は果実の抽出物を含有するイノシトール三リン酸受容体発現誘導剤、更に、マンダリンオレンジ抽出物のイノシトール三リン酸受容体の発現誘導作用を有する各種組成物(化粧料組成物、医薬組成物、飲食品組成物)。【選択図】なし