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PRODUCTION METHOD OF PREGABALIN-CONTAINING COMPOSITION AND PREGABALIN-CONTAINING COMPOSITION
专利权人:
NITTO DENKO CORPORATION
发明人:
Tomohito TAKITA,Kaiji FUJIWARA,Chie MATSUMOTO,Akinori SUGIYAMA,Jyun ISAYAMA,Toshinari HONDA,Ai FUNASAKI
申请号:
US16354275
公开号:
US20190290596A1
申请日:
2019.03.15
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Provided are a production method of a pregabalin-containing composition, which suppresses crystallization of pregabalin, and a pregabalin-containing composition that shows suppressed crystallization of Pregabalin. The production method of the pregabalin-containing composition of the present invention contains steps of:(1) dissolving pregabalin in an aqueous solution of an acid to prepare an aqueous solution of a salt of pregabalin; (2) mixing the aqueous solution of pregabalin salt and a hydrophilic resin to prepare a mixture thereof; and (3) concentrating the mixture; wherein the acid has an acid dissociation constant lower than that of pregabalin.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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