FRITSCHE Jens,SINGH Harpreet,WEINSCHENK Toni,MAHR Andrea,SCHOOR Oliver
申请号：
IL25757718
公开号：
IL257577D0
申请日:
2018.02.18
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide novel peptides for use in immunotherapeutic treatment of cancer.SOLUTION: The invention relates to a peptide comprising a specific amino acid sequence or a peptide comprising an amino acid sequence selected from the group consisting of variant sequences having at least 88% homology to the specific amino acid sequence, which peptide binds to a major histocompatibility complex (MHC) and/or induces a cross reaction between T cells and the peptide or pharmaceutically acceptable salt thereof, where the peptide is not the underlying full-length polypeptide. The invention further relates to a tumor-associated T-cell peptide epitope, alone or in combination with other tumor-associated peptides that can for example serve as an active pharmaceutical ingredient of a vaccine composition that stimulates anti-tumor immune responses, or stimulates T cells ex vivo for transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides alone, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.SELECTED DRAWING: None
