The present invention relates to a health functional food to prevent or alleviate tumor and, more specifically, relates to the health functional food comprising natural substances or an extract derived from natural substances which has no toxicity and has high antitumor activities. As such, the health functional food is suitable to prevent or alleviate the tumor. The health functional food to prevent or alleviate the tumor comprises: Coix lachryma-jobi var. ma-yuen, and Agaricus blazei murill.본 발명은 종양 예방 또는 개선용 건강기능성 식품에 관한 것으로서, 보다 상세하게는 천연물 또는 천연물 유래 추출물을 포함하여 독성이 없으며 높은 항종양 활성을 가져 종양 예방 또는 개선용으로 적합한 건강기능성 식품에 관한 것이다.