Volumetric Electromagnetic Phase Shift Spectroscopy (VEPS)-based methods of analyzing a tissue are provided. Aspects of the methods comprise obtaining a VEPS-based tissue classifier, or &ldquo；signature&rdquo； for a tissue at a single point in time. These methods find particular use in non-invasively determining the condition of a tissue, e.g. brain tissue, lung tissue, heart tissue, muscle tissue, skin tissue, kidney tissue, cornea tissue, liver tissue, abdomen tissue, head tissue, leg tissue, arm tissue, pelvis tissue, chest tissue, trunk tissue, prostate tissue, breast tissue, esophagus tissue, GI tract tissue, etc., in an individual. Devices and systems thereof that find use in practicing the subject methods are also provided.
