BONFANTI, JEAN-FRANCOIS,MULLER, PHILIPPE,FORTIN, JEROME MICHEL CLAUDE,DOUBLET, FREDERIC MARC MAURICE
申请号：
CA2612264
公开号：
CA2612264C
申请日:
2006.06.20
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Heterocyclylaminoalkyl Substituted Benzimidazoles Inhibitors of RSVreplication of formula (I): The salts and stereochemically isomeric formsthereof, wherein Q is hydrogen, C1-6alkyl optionally substituted with aheterocycle or Q is C1 -6alkyl substituted with both -OR4 and a heterocycle；wherein said heterocycle is oxazolidine, thiazolidine, 1-oxo-thiazolidine, 1,1-dioxothiazolidine, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, hexahydrooxazepine, hexahydrothiazepine, 1-oxo-hexahydrothiazepine, 1,1-dioxo-hexahydrothiazepine, pyrrolidine, piperidine,homopiperidine, piperazine； which heterocyle may be substituted with 1-2substituents； each Alk is C1 -6alkanediyl； R1 is Ar or optionally substitutedpiperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, pyridyl, pyrazinyl,pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl,thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazo lyl,oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl,benzimidazolyl, benzoxazolyl, benzthiazolyl, pyridopyridyl, naphthiridinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[1,2-a]pyridinylor 2,3-dihydro-1,4-dioxino[2,3-b]pyridyl； R3 is hydroxyC1 -6alkyl, C1 -6alkoxyC1-6alkyl, cyanoC1-6alkyl, aminocarbonyl-C1 -6-alkyl, mono-or di(C1 -6alkyl)aminocarbonyl-C1 -6- alkyl, carboxyl-C1 -6-alkyl, C1-6alkoxycarbonyl-C1-6 alkyl； R2, R4 and R5 are hydrogen or C1-6alkyl； Het is pyridyl, pyrazinyl,pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl,thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl,oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl,benzimidazolyl, benzoxazo lyl, benzthiazolyl, pyridopyridyl, naphthiridinyl,1H-imidazo[4,5-b]- pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[1,2-a]pyridinyl and 2,3-dihydro-1,4- dioxino[2,3-b]pyridyl； Ar is optionallysubstituted phenyl； pharmaceutical compos
