The present invention relates to compositions comprising Graptopetalum anduses thereof. Graptopetalum can protect animals from liver diseases andmedical conditions, such as inflammation, steatosis, and fibrosis. Inparticular, Graptopetalum inhibits proliferation of activated hepatic stellatecells, which play a pivotal role in liver fibrosis. Graptopetalum also hasanti-fibrosis activities as well as inhibits proliferation of lungfibroblasts. Therefore, in addition to being a prophylactic and therapeuticagent for the liver, Graptopetalum is useful against fibrosis or inflammationof tissues or organs other than the liver, in particular lung, kidney, andbladder. Other plants in the family of Crassulaceae, particularly Echeveria,have similar effects as Graptopetalum.
