VACINAS VIRAIS DERIVADAS DE CÉLULAS COM NÍVEIS BAIXOS DE ADN CELULAR RESIDUAL

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专利权人:

NOVARTIS VACCINES AND DIAGNOSTICS GMBH

发明人:

JENS-PETER GREGERSEN,HÓLGER KOST

申请号：

PT10075529

公开号：

PT2301572E

申请日:

2006.11.01

申请国别(地区):

PT

年份:

2014

代理人:

摘要：

The present invention relates to vaccine products for the treatment or prevention of viral infections. Further provided are methods of reducing contaminants associated with the preparation of cell culture vaccines. Residual functional cell culture DNA is degraded by treatment with a DNA alkylating agent, such as ²-propiolactone (BPL), thereby providing a vaccine comprising immunogenic proteins derived from a virus propagated on cell culture, substantially free of residual functional cell culture DNA.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/