VACCINS VIRAUX DERIVES DE CELLULES, PRESENTANT DE FAIBLES NIVEAUX D'ADN CELLULAIRE RESIDUEL

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专利权人:

NOVARTIS VACCINES AND DIAGNOSTICS GMBH

发明人:

申请号：

EP10075529.7

公开号：

EP2301572B1

申请日:

2006.11.01

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The present invention relates to vaccine products for the treatment or prevention of viral infections. Further provided are methods of reducing contaminants associated with the preparation of cell culture vaccines. Residual functional cell culture DNA is degraded by treatment with a DNA alkylating agent, such as ²-propiolactone (BPL), thereby providing a vaccine comprising immunogenic proteins derived from a virus propagated on cell culture, substantially free of residual functional cell culture DNA.

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中国工程科技知识中心

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http://www.ckcest.cn/home/