Devices, systems, kits and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ultrasound probe, such as an ocular probe for use in sonolysis, is disclosed that is for use in the eye and is configured to provide ultrasound with a frequency of between about 1.0 and about 3.0 MHz and with a mechanical index of between about 0.2 and about 0.6 MI. The probes, kits and systems are configured for delivery of ultrasound to the eye to activate microbubbles located at a site of a blockage within an ocular blood vessel to improve blood flow to an area of the eye.
