Anti-placenta-chondroitin-sulfate chimeric antigen receptor and application thereof

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专利权人:

Guangzhou Cas Lamvac Biotech Co.; Ltd.

发明人:

Yongchao Yao,Hemei Qi,Wenzhong Guo,Li Qin,Xiaoping Chen

申请号：

GB201810451

公开号：

GB2561755A8

申请日:

2016.10.26

申请国别(地区):

GB

年份:

2018

代理人:

摘要：

The present invention provides an anti-placenta chondroitin sulfate (pl-CS) chimeric antigen receptor and application thereof. The chimeric antigen receptor mainly comprises anti-pl-CS antigen recognition region, a hinge region, a transmembrane region and intracellular region, wherein the anti-pl-CS antigen recognition region is any one of a plasmodium protein VAR2CSA, a part of peptide segment of plasmodium protein VAR2CSA or a pl-CS antibody and the part of peptide segment of the plasmodium protein VAR2CSA is a peptide segment with the number of amino acid greater than 500 in the plasmodium protein VAR2CSA.

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