The present invention provides pharmaceutical combination compositions and Drug combinations for prophylaxis and/or treatment of dyslipidemic conditions such as high LDL lipemia in mammals including human. The present invention is related to pharmaceutical compositions for prophylaxis and/or treatment of dyslipidemia, which comprise (R)-2-[3-[[N-(benzoxazole-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid or a salt thereof, or a solvate thereof, and (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidine-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino]cyclohexyl}acetic acid, or a salt thereof, or a solvate thereof.[課題]本發明係提供一種組合醫藥組成物及藥劑併用,其係用於預防及/或治療於包含人類之哺乳動物中如高HDL血症之脂質異常狀態。本發明係關於一種脂質異常症等之預防及/或治療用醫藥組成物,其係含有(R)-2-[3-[[N-(苯并唑-2-基)-N-3-(4-甲氧基苯氧基)丙基]胺基甲基]苯氧基]丁酸或其鹽或該等之溶劑合物,及(S)-反式-{4-[({2-[({1-[3,5-雙(三氟甲基)苯基]乙基}{5-[2-(甲基磺醯基)乙氧基]嘧啶-2-基}胺基)甲基]-4-(三氟甲基)苯基}(乙基)胺基)甲基]環己基}醋酸或其鹽或該等之溶劑合物。
