The present invention concerns double stranded RNA compositions and transgenic plants capable of inhibiting expression of plants genes, and methods associated therewith. Specifically, the invention relates to the use of RNA interference to inhibit expression of a target plant gene which is a plant a CLASP1 gene, an Aspartic Proteinase Delta Subunit gene, a Secreted Protein 1 gene, a Lectin Receptor Kinase-like gene, a Pectin Methylesterase-like gene, and an N PY1 gene, and relates to the generation of plants that have increased resistance to parasitic nematodes.Composiciones de ARN bicatenario y plantas transgénicas capaces de inhibir la expresión de genes vegetales, y métodos asociados con ellas. Específicamente, el uso de ARN de interferencia para inhibir la expresión de un gen blanco vegetal que es un gen CLASP1, un gen de la subunidad delta de proteinasa aspártica, un gen de la proteína 1 secretada, un gen tipo receptor de quinasa lectina, un gen tipo pectina metilesterasa y un gen NPY de planta, y la generación de plantas que tienen mayor resistencia a los nematodos parasitarios.