The present invention concerns double stranded RNA compositions and transgenic plants capable of inhibiting expression of plants genes and methods associated therewith. Specifically the invention relates to the use of RNA interference to inhibit expression of a target plant gene which is a plant a CLASP1 gene an Aspartic Proteinase Delta Subunit gene a Secreted Protein 1 gene a Lectin Receptor Kinase-like gene a Pectin Methylesterase-like gene and an N PY1 gene and relates to the generation of plants that have increased resistance to parasitic nematodes.