Jaroslaw Maciejewski,Babal K. Jha,James G. Philips,Thomas Radivoyevitch,Yihong Guan,Anand D. Tiwari
申请号：
US16768112
公开号：
US20200306221A1
申请日:
2018.11.29
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A method of treating cancer is described. The method includes administering a therapeutically effective amount of a TET2 activating compound or pharmaceutically acceptable salt thereof to a subject in need of treatment. The TET2 activating compounds are a-ketoglutarate derivatives. A method of treating or preventing cancer in a subject that includes the step of analyzing a biological sample to determine if cells of the biological sample exhibit a TET2 mutation in addition to administering a TET2 activator is also described.
