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СПОСОБ ПОЛУЧЕНИЯ БЛОК-СОПОЛИМЕРА
专利权人:
NIPPON KAYAKU KABUSIKI KAJSYA
发明人:
YAMAMOTO Kejitirou,ЯМАМОТО Кейитироу,KITAGAVA Masayuki,КИТАГАВА Масаюки
申请号:
RU2014114264
公开号:
RU0002623426C2
申请日:
2012.08.31
申请国别(地区):
RU
年份:
2017
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: block copolymer has the following formula (1):,where R1 is a hydrogen atom or a (C1-C5) alkyl group R2 is a (C1-C5) alkylene group R3 is a methylene or ethylene group R4 represents a hydrogen atom or a (C1-C4) acyl group R5 is a hydroxyl group, an aryl (C1-C8) alkoxy group which may have a substituent, or -N (R6) -CO-NHR7, where R6 and R7 may be the same or different and each represents a cyclic (C3-C6) An alkyl group or a (C1-C5) alkyl group which may be substituted with a tertiary amino group N is 20-500 M is 2-200 But is 0-100 B is 0-100, provided that the sum of a and b is greater than or equal to 1 and not more than m The fraction of the R5 group representing the hydroxyl group is 0-5% of m proportion of the R5 group representing an aryl (C1-C8) alkoxy group which may have a substituent is 10-80% of m The fraction of the R5 group representing -N (R6) -CO-NHR7 is 11-30% of m. The process for preparing the block copolymer is that the compound of the formula (2)is reacted, wherein R1, R2, R3, R4, n are as defined above x is 0-100, y is 0-100, the sum of x and y is 2-200, with aryl (C1-C8) alkyl alcohol, and a carbodiimide-based compound in an amount of 2(x+y) equivalents or more relative to the amount of carboxyl Groups in the compound of formula (2). The reaction is carried out in a solvent at a temperature of 15-30°C for 2-48 hours.EFFECT: invention allows to maintain the process in a single reactor, reduce manufacturing period and reduce the quantity of solvent.4 cl, 1 tbl, 6 exИзобретение относится к способу получения блок-сополимера, который может быть использован для получения противоракового лекарственного средства. Блок-сополимер имеет следующую формулу (1):,где R1 представляет собой атом водорода или (С1-С5)алкильную группу R2 представляет собой (С1-С5)алкиленовую группу R3 представляет собой метиленовую или этиленовую группу R4 представляет собой атом водорода или (С1-С4)ацильную группу R5 представляет собой гидроксильную груп
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