A device and a method for early electrophysiological detection of chronic disease. The device comprises a plurality of electrodes (101), a detection apparatus (102), and a signal source (103), the plurality of electrodes (101) being arranged at a measurement position determined according to the target of the chronic disease early electrophysiological detection the detection apparatus (102) comprises a sending module (1021), a collecting module (1022), a microprocessor (1023), and a display module (1024), the sending module (1021) controlling the signal source (103) to emit measurement signals of different frequencies in order to measure, on the basis of a preset combination of human body resistor networks, the resistance value between the electrodes (101) at the measurement position corresponding to each human body resistor network the collection module (1022) collects the resistance values the microprocessor (1023) determines the results of the electrophysiological detection on the basis of the amount of change to the resistance values at different frequencies and the display device (1024) receives and displays the results of the electrophysiological detection. The device and method measure pathological changes or the state of health of local body tissues in a targeted manner, such that detection results are more accurate and measurement efficiency is high.Linvention concerne un procédé de détection électrophysiologique dun stade précoce dune maladie chronique, un dispositif et un système associés. Cet appareil comprend une pluralité délectrodes (101), un dispositif de détection (102) et une source du signal (103), ladite pluralité délectrodes (101) se trouvant à lemplacement de mesure étalonnée avec un article donné de détection électrophysiologique dun stade précoce dune maladie chronique et ledit dispositif de détection (102) comportant un module denvoi (1021), un module de collecte (1022), un microprocesseur (1023) et un module daffichage (1024), le module denv
