Disclosed is a protein hydrolysate having DPP-IV inhibiting activity, the hydrolysate being enriched in peptides having a length of 2-8 amino acids comprising at least one proline residue, an isolated peptide derivable from such a protein hydrolysate, or a mixture thereof, and the use of such protein hydrolysate or isolated peptide for the manufacture of a medicament, food supplement, beverage or food product for prophylaxis and/or treatment of a DPP-IV mediated condition, in particular chosen from the group of obesity, type 2 diabetes mellitus and an immunological disorder.本發明揭露一種具有二肽醯肽酶IV抑制活性之蛋白水解物，前述水解物富含具有2-8個胺基酸之長度且包含至少一個脯胺酸殘基之胜肽；揭露一種來源於前述蛋白水解物之經分離胜肽或其混合物；且揭露一種前述蛋白水解物或經分離胜肽用以製造用於預防及/或治療尤其選自肥胖、第二型糖尿病及免疫病狀之族群之二肽醯肽酶IV介導性病症之藥物、膳食補充劑、飲料或食物產品的用途。
