Steven Jacobs,Karyn O'Neil,Michael Baumann,Gaby Sennhauser,Karyn ONeil
申请号:
US13458578
公开号:
US20120277143A1
申请日:
2012.04.27
申请国别(地区):
US
年份:
2012
代理人:
摘要:
IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.