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IL4/IL13 binding repeat proteins and uses
专利权人:
Janssen Biotech; Inc.
发明人:
Michael Baumann,Gaby Tresch,Steven Jacobs,Karyn O'Neil,Karyn ONeil
申请号:
US14225821
公开号:
US09206244B2
申请日:
2014.03.26
申请国别(地区):
US
年份:
2015
代理人:
摘要:
IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.
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