A device, a system and a method for in-vivo examination. A method for in-vivo examinationincludes substantially emptying a subject's colon from content, and insertingan autonomous in-vivo imaging device into the subject's gastrointestinaltract. An in-vivo examination kit includes an autonomous in-vivo imaging device,a wireless receiver, an antenna set, a laxative, and optionally a stimulant andan instructions leaflet.
