The United States of America, as Represented by the Secretary of Agriculture;Los Alamos National Security, LLC
发明人:
RIEDER, Aida E.,FISCHER, William M.,RAI, Devendra K.
申请号：
EP17865047
公开号：
EP3532484A4
申请日:
2017.10.25
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. The mosaic polypeptides have greater T-cell epitope coverage than naturally occurring FMDV polypeptides, and include common FMDV epitopes, but exclude rare FMDV epitopes. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype A FMDV strains.
