THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
发明人:
CHUNG, HYO KYUNKR,정효균,SHONG, MIN HOKR,송민호,KIM, KOON SOONKR,김군순,KWEON, GI RYANGKR,권기량
申请号：
KR1020150090349
公开号：
KR1020170001021A
申请日:
2015.06.25
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
A sarcopenia animal model of the present invention has no problems with the gender ratio and appearances, shows specific symptoms of sarcopenia since an amount, quantity of motion and mobility of myocytes are reduced according to the growth, and can be used for an animal model for the research of the progress of sarcopenia and pathological operandi research and screening of a medicine for preventing and treating sarcopenia. To this end, the sarcopenia animal model has myocyte-specifically knocked out CR6 interacting factor 1 (CRIF1) gene.COPYRIGHT KIPO 2017본 발명의 근감소증 동물 모델은 출생시에는 성비 및 외형에 이상이 없으면서 성장에 따라 근세포의 양, 운동량 및 운동력이 감소하여 근감소증 고유의 증상을 나타내므로 근감소증 진행 경과, 병리학적 기전 연구의 동물 모델 및 근감소증 예방 및 치료제의 스크리닝에 유용하게 이용될 수 있다.
