PROBLEM TO BE SOLVED: To provide a method of making a non-human animal with abnormality in brain tissue, and use thereof.SOLUTION: The present invention provides a method of making a non-human animal with abnormality in brain tissue, the method including the step of administering, to a non-human animal, at least one material of saccharides selected from monosaccharides, disaccharides and oligosaccharides, and artificial sweeteners.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2018,JPO&INPIT【課題】脳組織の異常を伴う非ヒト動物の作製方法およびその利用を提供する。【解決手段】本発明の脳組織の異常を伴う非ヒト動物の作製方法は、非ヒト動物に単糖類、二糖類およびオリゴ糖から選択される糖類ならびに人工甘味料のうちの少なくともいずれか1つの物質を投与する工程を包含する。【選択図】図1
