Kaufmann, Gunnar Jorg Floris,Fu, Yanwen,Zhang, Yan-Iiang,Patterson, James T.
申请号：
AU2016341321
公开号：
AU2016341321A1
申请日:
2016.10.24
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention provides programmable universal cell receptors (PUCRs) comprising a catalytic antibody region, a transmembrane domain and a cytoplasmic domain. The PUCRs disclosed herein may be conjugated to a specificity agent in order to program the receptor for specificity to any molecule of interest. Also provided are nucleic acids encoding such PUCRs, and cells expressing the PUCRs. Such cells may be used in treating a variety of medical conditions and diseases including cancer and infectious diseases.
