О'НЕЙЛ Джеймс Деннен (US),БАМАТ Майкл К. (US),ВОН БОРСТЕЛ Рейд В. (US),ШАРМА Шалини (US),АРУДЧАНДРАН Рамачандран (US),ОНЕЙЛ Джеймс Деннен (US)
申请号：
RU2010141823/13
公开号：
RU2010141823A
申请日:
2009.03.13
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method of reducing the concentration of uric acid in the blood or increasing the excretion of uric acid in a mammalian patient, comprising administering to the patient a compound of formula I or a pharmaceutically acceptable salt thereof! ! where m is 0, 1, 2, 3 or 4； ! n is 0 or 1； ! m + n no more than 4； ! t is 0 or 1； ! q is 0 or 1； ! r is 0, 1 or 2； ! R6 is hydrogen, methyl or ethyl, and R12 is hydrogen or methyl, or R6 is hydroxy, and R12 is hydrogen, or R6 is O and R12 is absent, or R6 and R12 together are —CH2CH2—； ! R7 is hydrogen or alkyl containing from 1 to 3 carbon atoms； ! one of R8 and R9 is alkyl containing from 1 to 3 carbon atoms, and the other is hydrogen or alkyl containing from 1 to 3 carbon atoms； ! R10 is hydrogen, halogen, alkyl containing from 1 to 3 carbon atoms or alkoxy containing from 1 to 3 carbon atoms； ! X is C (O) and r is 0 and t is 0； or NH (R11), where R11 is hydrogen or alkyl containing from 1 to 3 carbon atoms； ! A is phenyl unsubstituted or substituted by 1 or 2 groups selected from halogen, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy and perfluoromethoxy； or ! A 5- or 6-membered heteroaromatic ring containing 1 or 2 heteroatoms in the ring selected from N, S and O, and the heteroaromatic ring is covalently linked to the remainder of the compounds of formula I via a carbon atom of the ring； or ! cycloalkyl containing from 3 to 6 carbon atoms in the ring, where cycloalkyl is unsubstituted, or one or two carbon atoms of the ring are independently monosubstituted with methyl or ethyl； ! in an amount effective to reduce the concentration of uric acid in the blood or increase the excretion of m1. Способ снижения концентрации мочевой кислоты в крови или увеличения выведения мочевой кислоты у млекопитающего пациента, включающий введение пациенту соединения формулы I или его фармацевтически приемлемой соли ! ! где m равно 0, 1, 2, 3 или 4； ! n равно 0 или 1； ! m+n не более 4； ! t равно 0 или 1； ! q равно 0 или
