PROBLEM TO BE SOLVED: To provide a fusion protein formed by coupling of a c-Met antibody and a VEGF-binding fragment.SOLUTION: There are provided a fusion protein formed by coupling of an anti-c-Met antibody and a VEGF-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-Met and VEGF at the same time, with improved anticancer and anti-angiogenesis effects, comprising a step of coupling the anti-c-Met antibody with the VEGF-binding fragment.SELECTED DRAWING: Figure 2ACOPYRIGHT: (C)2018,JPO&INPIT【課題】 ｃ－Ｍｅｔ抗体およびＶＥＧＦ結合断片が連結された融合タンパク質の提供。【解決手段】 抗－ｃ－Ｍｅｔ抗体とＶＥＧＦ結合断片が連結された融合タンパク質、前記融合タンパク質を含む二重特異性抗体、前記融合タンパク質をコードするポリヌクレオチド、前記ポリヌクレオチドを含む形質転換体、前記二重特異性抗体を有効成分として含む医薬組成物、および抗－ｃ－Ｍｅｔ抗体にＶＥＧＦ結合断片を連結するステップを含む抗がんおよび新生血管抑制効能が改善されたｃ－ＭｅｔとＶＥＧＦを同時に標的とする二重特異性抗体の製造方法。【選択図】 図２Ａ
