Ghasparian, Arin,Boato, Francesca,Robinson, John A.,Freund, Annabelle,Thomas, Richard M.,Mohle, Kerstin
申请号：
AU2007327829
公开号：
AU2007327829B2
申请日:
2007.12.06
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The invention relates to lipopeptide building blocks consisting of a peptidechain comprising a coiled-coil domain, linked covalently to a lipid moiety comprisinglong alkyl or alkenyl chains, and optionally linked to an antigen； and to helicallipopeptide bundles and synthetic virus-like particles formed by aggregation.The nanometer size and shape of these bundles and particles, their stabilityunder aqueous physiological conditions, their chemical composition, the possibilityto incorporate B- and T-cell epitopes, and their production by chemical synthesis,make them highly suitable as vaccine delivery vehicles.
