The present invention is concerned with spiro-dihydrotetraazabenzoazulene derivatives, i.e. spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene derivatives of formula Iwherein R1, R2, R3, X, Y, z, m and n are as described herein. The compounds according to the invention act as V1a receptor modulators and are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.本發明係關於一種螺-二氫四氮雜苯并薁衍生物，亦即式I之螺-5,6-二氫-4H-2,3,5,10b-四氮雜-苯并[e]薁衍生物，其中R1、R2、R3、X、Y、Z、m及n係如本文所述。本發明之化合物可充當V1a受體調節劑且適用作以下之病狀的於周邊與中樞發揮作用之治療劑：痛經、男性或女性性功能障礙、高血壓、慢性心臟衰竭、血管加壓素分泌不當、肝硬化、腎病症候群、焦慮症、憂鬱症、強迫症、自閉症系列障礙、精神分裂症及攻擊行為。
