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5′-dibenzyl phosphates of 5-azacytidine or 2′-deoxy-5-azacytidine
专利权人:
OHARA PHARMACEUTICAL CO.; LTD.
发明人:
Magoichi Sako,Xiong Luo
申请号:
US15355326
公开号:
US09670238B1
申请日:
2016.11.18
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention relates to a novel compound represented by formula (1), or salt thereof,wherein R is hydroxy group or hydrogen atom; R1 and R2 are the same or different, and are each independently benzyl group which may have a substituent. The present invention provides therapeutically agents, which have remarkable stability against cytidine deaminase, a metabolic enzyme, can be absorbed in vivo by oral administration and inhibit protein synthesis by being incorporated easily into nucleic acid bio-synthesis in vivo for replacing injection agent (5-azacytidine or 2′-deoxy-5-azacytidine) used in clinic for treating myeloma.
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