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NOVEL DNMT INHIBITOR AS SOLID TUMOR THERAPEUTIC DRUG
专利权人:
NATIONAL CANCER CENTER;OHARA PHARMACEUTICAL CO., LTD.
发明人:
SAKO MAGOICHI,TOSHIKAZU USHIJ1MA,NAOKO HATTORI
申请号:
US16607007
公开号:
US20200061093A1
申请日:
2018.04.24
申请国别(地区):
US
年份:
2020
代理人:
摘要:
[Problem]To provide, in place of injected agents (such as Vidaza® and Dacogen®) clinically used as therapeutic drugs for high-risk myelodysplastic syndromes, a medicine as a therapeutic drug or a prophylactic drug for various advanced solid tumors, said medicine having high stability with respect to cytidine deaminase which is a hydrolytic metabolic enzyme, being absorbed into the body even by oral administration, and having an effect of being integrated into a nucleic acid biosynthetic route and inhibiting DNA methyltransferases, i.e., DNMTs.[Solution]The aforementioned problem is solved by a novel compound represented by formula (I). (In the formula, R is a hydroxyl group or a hydrogen atom, and R1 and R2 are each a benzyl group that may have a substituent.)
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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