MUNOZ BLANCO, EDUARDO,NAVARRETE RUEDA, CARMEN MARIA,CRUZ TENO, CRISTINA,BELLIDO CABELLO DE ALBA, MARIA LUZ
申请号：
CA3058352
公开号：
CA3058352A1
申请日:
2017.03.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Cannabidiol quinol derivatives of Formula (I) and compositions comprising the same for use in the treatment of conditions that benefit from the inhibition of the HIF prolyl hydroxylases (PHDs) activity are described. Said cannabidiol quinol derivatives of Formula (I), and compositions comprising the same, show thus capacity to inhibit PHD activities and, as a result, stabilize the HIF- 1a and HIF-2a levels, activate the HIF pathway in different cell types, induce angiogenesis in human endothelial vascular cell, regulate HIF-dependent gene expression in different cell types 10 and induce collagen contraction. Said cannabidiol quinol derivatives of Fomula (I) are useful in the treatment of conditions that benefit from the inhibition of the HIF prolyl hydroxylases (PHDs) activity such as stroke, traumatic injuries anemia, myocardial ischaemiareperfusion injury, acute lung injury, infectious diseases, diabetic and chronic wounds, organ transplantation, acute kidney injury or arterial diseases.
