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INDUSTRIAL PROCESS FOR PREPARATION OF 1,2-DIHYDROQUINOLINE DERIVATIVE OR A SALT THEREOF, AND INTERMEDIATE FOR PREPARATION THEREOF
专利权人:
发明人:
申请号:
EP13738250.3
公开号:
EP2805948A1
申请日:
2013.01.21
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Provided is a method for producing a compound represented by formula (7) or a salt thereof:the method comprising the steps of:removing a R1 group and a R2 group from a compound represented by formula (5) or a salt thereof:andreacting the compound (in which R1 and R2 in formula (5) are hydrogen atoms) obtained in the removing step or a salt thereof with a compound represented by formula (d):or a salt thereof in the presence of a base. The method is a method for producing a 1,2-dihydroquinoline derivative having glucocorticoid receptor binding activity or a salt thereof. This method does not require a purification step by column chromatography and is suitable for industrial production.
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