Megan Alene Cloonan Foley,Kevin Wayne Kuntz,Lorna Helen Mitchell,Michael John Munchhof
申请号：
US15510605
公开号：
US10106510B2
申请日:
2015.09.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure provides substituted cyclohexylamine compounds having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, R5, and R7 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
