CHESWORTH, RICHARD,FOLEY, MEGAN ALENE CLOONAN,KUNTZ, KEVIN WAYNE,MITCHELL, LORNA HELEN,PETTER, RUSSELL C.,SCHWARTZ, CARL ERIC
申请号：
CA2960279
公开号：
CA2960279A1
申请日:
2015.09.09
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present disclosure provides provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
