PREPARATION OF IODIXANOL

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专利权人:

GE HEALTHCARE AS

发明人:

HOMESTAD, OLE MAGNE

申请号：

HU0105096

公开号：

HU228226B1

申请日:

2000.02.10

申请国别(地区):

HU

年份:

2013

代理人:

摘要：

A process for the preparation of iodixanol by dimerisation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide ("Compound A") in which, after the dimerisation step, unreacted Compound A is precipitated from the reaction mixture and recovered for re-use. The process substantially increases the net yield of iodixanol and simplifies its purification.

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