David FRENDEWEY,David M. VALENZUELA,Guochun GONG,John RINN,Ka- Man VENUS LAI
申请号：
MX2016001682
公开号：
MX2016001682A
申请日:
2014.08.07
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs. Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs. The present invention provides compositions and methods for the diagnosis of colorectal cancer in a subject. In one embodiment, the method includes detecting methylation status of one or more genes in a sample to diagnosis the subject. The invention further relates to DNA methylation as a predictor of disease recurrence and patient prognosis, specifically in the field of cancer biology.Se proporcionan animales no humanos modificados genéticamente que exhiben una carencia funcional de uno o varios IncRNA. Se proporcionan métodos y composiciones para alterar, suprimir y/o reemplazar secuencias que codifican IncRNA. Se proporcionan ratones modificados genéticamente que envejecen prematuramente. También se proporcionan células, tejidos y embriones que están modificados genéticamente para comprender una pérdida de función de uno o varios IncRNA.
