您的位置: 首页 > 农业专利 > 详情页

APPLICATIONS OF IMMUNO CONJUGATES WHICH ARE THE TARGET OF CD138
专利权人:
ИММУНОДЖЕН, ИНК. (US);БИОТЕСТ АГ (DE)
发明人:
ОСТЕРРОТ Франк (DE),УЭРЕК Кристоф (DE),БРЮХЕР Кристоф (DE),ДЕЛКЕН Бенжамин (DE),ЭНГЛИНГ Андре (DE),ХЕДЕР Томас (DE),ВАРТЕНБЕРГ-ДЕМАНД Андреа (DE),НИМАНН Габриэле (DE),ЦУБЕР Шанталь (DE),ЧЕЛОТ Никлас (
申请号:
RU2011149471/02
公开号:
RU2011149471A
申请日:
2010.05.05
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of treating a disease associated with target cells expressing CD138, comprising: administering to a patient in need an effective amount of an immunoconjugate containing at least one targeting agent, the targets of which are cells expressing CD138, and at least one effector molecule, wherein said targeting agent operably linked to said effector molecule to form said immunoconjugate, and wherein said effective amount is an acceptable amount. 2. The method according to claim 1, wherein the immunoconjugate is administered to an individual in an amount of 5-200 mg / mile pharmacokinetically equivalent to 5-200 mg / m when administered in combination with an agent for treating adverse side effects. The method according to claim 1 or 2, where the maximum concentration of immunoconjugate in an individual’s plasma between 0 and 2 hours after completion of the first administration is less than 50%, preferably less than 40%, more preferably less than 30%, even more preferably less than 20% or even less than 10 % of theoretical maximum concentration of the indicated immunoconjugate. 4. The method according to claim 3, in which the immunoconjugate is administered at least four times, and the maximum concentration of the immunoconjugate in an individual's plasma between 0 and 2 hours after completion of each of these administrations is less than 55%, more preferably less than 50%, more preferably less than 40%, even more preferably, less than 30%, less than 20%, or even less than 10% of the theoretical maximum concentration of said immunoconjugate. 5. The method according to claim 1, where the specified immunoconjugate is administered in a dose, preferably in a repeated single dose of not more than pr1. Способ лечения заболевания, связанного с клетками-мишенями, экспрессирующими CD138, предусматривающий:введение нуждающемуся пациенту эффективного количества иммуноконъюгата, содержащегопо крайней мере один нацеливающий агент, мишенями которого являются клетки, экспресс
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充