Apparatus and methods for vibro-acoustic detection of cardiac conditions are disclosed. An example method includes calculating a frequency difference between a first frequency of a first cardiac signal and a second frequency of a second cardiac signal calculating an amplitude difference between the first cardiac signal and the second cardiac signal calculating a root-mean-square value based on a difference between the first cardiac signal and the second cardiac signal calculating a value based on the frequency difference, the amplitude difference, and the root-mean-square value and detecting a cardiac condition based on the value.
