Disclosed is a vaccine vector comprising an antigenic polypeptide and an HMGB 1 polypeptide or a functional fragment thereof, wherein at least a portion of the antigenic polypeptide and at least a portion of the HMGBI polypeptide are present on the surface of the vaccine vector. Further disclosed is a Bacillus spp. vaccine vector comprising a first polynucleotide sequence encoding an antigenic polypeptide present on the surface of the vaccine vector and a second polynucleotide sequence encoding an immunostimulatory polypeptide, wherein the antigenic polypeptide and the immunostimulatory polypeptide are present on the surface of the vaccine vector, wherein the antigenic polypeptide is an Influenza polypeptide and wherein the immunostimulatory polypeptide is a CD154 polypeptide or a HMGB1 polypeptide.
