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Composition and Method for Mediating an Immune Response
专利权人:
CAMILO COLACO
发明人:
CAMILO COLACO
申请号:
US13470227
公开号:
US20120225067A1
申请日:
2012.05.11
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides a fusion protein comprising an Fc receptor binding polypeptide and an antigenic polypeptide. The fusion protein may further comprise a linker sequence or hinge portion which joins the Fc receptor binding polypeptide and the antigenic polypeptide. The Fc receptor binding polypeptide typically comprises the CH2 constant domain of a human IgG immunoglobulin. The antigenic polypeptide can be any polypeptide which induces an immune response. Administration of the fusion protein to a subject results in a cytotoxic T lymphocyte response being induced against the antigenic polypeptide provided within the fusion protein. The invention further extends to methods for the treatment of a disease condition in a subject using the fusion proteins of the invention.
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